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Gene expression profiling from high-fat medium (HFM)-treated and growth medium (GM)-treated Sk-hep1 cells

ABSTRACT: Non-alcoholic fatty liver disease (NAFLD) is a major problem in obese peoples and caused by unbalanced uptake of fatty acid. Novel drug identification is necessary to develop effective therapies. We combine LOPAC® and High-Content system to identify compounds significantly reducing intracellular lipid droplets after high fat medium (HFM) treatment. Among 1280 compounds, 5 show efficacy in lipid droplet reduction. To construct the underlying regulatory network, whole-genome transcriptomic, pathway, and connectivity map analysis are performed.

ORGANISM(S): Homo sapiens

PROVIDER: GSE109836 | GEO | 2018/01/31

REPOSITORIES: GEO

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Gene expression profiling from high-fat medium (HFM)-treated and growth medium (GM)-treated Sk-hep1 cells

Project description:Gene expression profiling from high-fat medium (HFM)-treated and growth medium (GM)-treated Sk-hep1 cells

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Overexpression of modified human TRβ1 suppresses the growth of hepatocarcinoma SK-hep1 cells in vitro and in xenograft models.

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Amentoflavone enhances sorafenib-induced apoptosis through extrinsic and intrinsic pathways in sorafenib-resistant hepatocellular carcinoma SK-Hep1 cells <i>in vitro</i>.

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