Expression data of cystic renal epithelial tissue from mice deficient for fumarate hydratase.

ABSTRACT: Fumarate hydratase (FH) mutations cause hereditary leiomyomatosis and renal cell cancer (HLRCC). We have conditionally inactivated the murine ortholog (Fh1) in renal tubular epithelial cells in order to generate an in vivo model of HLRCC. Fh1 knockout mice recapitulates important aspects of HLRCC including the development of renal cysts that overexpress hypoxia inducible factor alpha (Hifa) and Hif-target genes. We used microarrays to detail the global programme of gene expression underlying cyst development in Fh1 knockout mice and identified distinct classes of up-regulated genes during this process. Keywords: gene expression, comparison (wild-type n=3 vs knockout n=3)

ORGANISM(S): Mus musculus

PROVIDER: GSE10989 | GEO | 2010/12/22

SECONDARY ACCESSION(S): PRJNA107197

REPOSITORIES: GEO