Intergrated epigenetics, transcriptomics and metabolomics to analyze the mechanism of Benzo[a]pyrene neurotoxicity in hippocampus

ABSTRACT: Purpose: The aim of the study was to investigate the global effect of B[a]P on DNA methylation, non-coding RNAs (ncRNAs) and coding RNAs expression in the rat hippocampus. Methods: High-throughput sequencing was applied to assess hippocampus DNA methylation, ncRNAs and coding RNAs expression. Results: Exposure to B[a]P could influence the levels of DNA methylation, and the expression profiles of ncRNAs and mRNAs in rats. Conclusions: B[a]P could bring on the epigenetics changes as well as the transcriptomics changes and further affected gene expression.

ORGANISM(S): Rattus norvegicus

PROVIDER: GSE109973 | GEO | 2020/02/21

REPOSITORIES: GEO