Glatiramer Acetate modulates ion channel expression and calcium homeostasis in B-cell of patients with relapsing-remitting multiple sclerosis

ABSTRACT: In order to investigate the effects of Glatiramer acetate (GA) in treatment-naïve RR-MS female patients’ B cells we performed Affymetrix Gene-Chip Human Genome HG-U133A_2 hybridization experiments Transcriptome analysis before and after acute (six hours in vitro) and chronic (six months in vivo) treatment with GA. We compared the transcriptional profiles of B cells, from the above-mentioned patients, treated or not with GA for 6 hours in vitro, and before and after six months of GA treatment in vivo.

ORGANISM(S): Homo sapiens

PROVIDER: GSE110023 | GEO | 2018/11/30

REPOSITORIES: GEO