Impaired TNFa-driven dendritic cell activation limits LPS-induced protection from asthma in infants.

ABSTRACT: We found that approximately 200 genes were differentially expressed between CD11b+ lung-migratory dendritic cells (CD11b+ mDCs) from adult and infant mice treated with house dust mite allergen + LPS, and that the TNFa-via NFkB signaling pathway was significantly enriched in CD11b+ mDCs from adults relative to those from infants. Specifically, out of the 200 genes in the hallmark TNFa-via NFkB signaling pathway that were analyzed, 31 genes were significantly downregulated in CD11b+ mDCs from infants compared to CD11b+ mDCs from adults.

ORGANISM(S): Mus musculus

PROVIDER: GSE110046 | GEO | 2019/01/08

REPOSITORIES: GEO