Dataset Information


CLIP analysis of AEG1

ABSTRACT: Includes HITS-CLIP and PAR-CLIP of AEG1, including negative controls Overall design: AEG-1 bound RNA profiles examinated by HITS-CLIP and PAR-CLIP, coupled with deep sequencing, in duplicate for HITS-CLIP, using Illumina HiSeq.

INSTRUMENT(S): Illumina HiSeq 2500 (Homo sapiens)

SUBMITTER: David Reid 

PROVIDER: GSE110260 | GEO | 2018-02-08


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Oncoprotein AEG-1 is an endoplasmic reticulum RNA-binding protein whose interactome is enriched in organelle resident protein-encoding mRNAs.

Hsu Jack C-C JC   Reid David W DW   Hoffman Alyson M AM   Sarkar Devanand D   Nicchitta Christopher V CV  

RNA (New York, N.Y.) 20180207 5

Astrocyte elevated gene-1 (AEG-1), an oncogene whose overexpression promotes tumor cell proliferation, angiogenesis, invasion, and enhanced chemoresistance, is thought to function primarily as a scaffolding protein, regulating PI3K/Akt and Wnt/β-catenin signaling pathways. Here we report that AEG-1 is an endoplasmic reticulum (ER) resident integral membrane RNA-binding protein (RBP). Examination of the AEG-1 RNA interactome by HITS-CLIP and PAR-CLIP methodologies revealed a high enrichment for e  ...[more]

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