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Expression data comparing control (day 0) and active (day 3) liver regeneration in mice that have undergone partial hepatectomy

ABSTRACT: Identification of altered gene expression of normal and regenerating liver post partial hepatectomy Platform used - Affymetrix GeneChip Mouse Genome 430 2.0 Array

ORGANISM(S): Mus musculus

PROVIDER: GSE110292 | GEO | 2021/01/01

REPOSITORIES: GEO

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Expression data from rat hepatocyte during liver regeneration after partial hepatectomy

Project description:The recovery of liver mass is mainly mediated by proliferation and enlargement of hepatocytes after partial hepatectomy. Studying the gene expression profiles of hepatocytes after partial hepatectomy will be helpful in exploring the mechanism of liver regeneration. We used microarrays to further highlight the regulatory role of hepatocyte in liver regeneration at gene transcription level. Rat liver regeneration after partial hepatectomy (PH) is a good model to study the regulation of cell proliferation. We isolated hepatocytes from regenerating liver at 9 time points (2, 6, 12,24, 30, 36, 72, 120, and 168h) after PH and measured gene expression profiles of hepatocytes from 2h to 168h with rat Genome 230 2.0 gene chip. Each sample corresponding to one time point was hybridized onto one array. The experiment was repeated 3 times for each time point. In total, 10 time points were measured and 0h was used control group. After careful quality control analyses of each chip, Affymetrix GCOS 2.0 software was used to analyze the data. The relevance of gene expression profiles and biological processes was analyzed by bioinformatics and systems biology.

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Transcription profiling of mouse liver regeneration after partial hepatectomy

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Expression data comparing control (day 0) and active (day 3) liver regeneration in mice that have undergone partial hepatectomy

Project description:Expression data comparing control (day 0) and active (day 3) liver regeneration in mice that have undergone partial hepatectomy

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Genome wide analysis of liver histone H3K9 acetylation after partial hepatectomy in glucose-treated and control mice.

Project description:We report the results of AcH3K9 ChIP-Seq on regenerating liver harvested 12 h after partial hepatectomy (PH) from mice treated with supplemental parenteral dextrose (to delay onset of PH-induced hypoglycemia) or vehicle (as control). Examination of the effect of delaying PH-induced hypoglycemia on histone H3K9 acetylation in regenerating liver.

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Expression data from rat hepatocyte during liver regeneration after partial hepatectomy

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Characterization of hepatic gene expression during liver regeneration in response to partial hepatectomy

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Genome wide analysis of liver histone H3K9 acetylation after partial hepatectomy in glucose-treated and control mice.

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Comparison of hepatic gene change after partial hepatectomy

Project description:Partial hepatectomy, resection of a portion of liver mass, indues significant liver regenerative responses that consist of numerous genetic changes. To identify specific genetic changes, we compare the liver of mice underwent either hepatectomy or sham operation.

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Expression data from rat liver tissue during liver regeneration after partial hepatectomy.

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