Genomics

Dataset Information

37

Analysis of differential gene expression in the Streptococcus sanguinis brpL mutant


ABSTRACT: Gene expression profile of the Streptococcus sanguinis transcription regulator, brpL, deletion mutant compared to the wild-type strain SK36 Overall design: Experiment: brpL mutant vs. wild-type SK36. Biological replicates independently grown and prepared for each sample.

INSTRUMENT(S): Illumina HiSeq 2000 (Streptococcus sanguinis)

SUBMITTER: Ping Xu  

PROVIDER: GSE110307 | GEO | 2018-06-14

REPOSITORIES: GEO

Dataset's files

Source:
Action DRS
GSE110307_RNA-seq_SSA_0427.txt.gz Txt
GSE110307_SSA_0427_normalized_read_counts_RPKM.txt.gz Txt
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Publications

A Novel Regulator Modulates Glucan Production, Cell Aggregation and Biofilm Formation in Streptococcus sanguinis SK36.

Zhu Bin B   Song Lei L   Kong Xiangzhen X   Macleod Lorna C LC   Xu Ping P  

Frontiers in microbiology 20180529


Streptococcus sanguinis is an early colonizer of tooth surfaces and a key player in plaque biofilm development. However, the mechanism of biofilm formation of S. sanguinis is still unclear. Here, we showed that deletion of a transcription factor, brpL, promotes cell aggregation and biofilm formation in S. sanguinis SK36. Glucan, a polysaccharide synthesized from sucrose, was over-produced and aggregated in the biofilm of ΔbrpL, which was necessary for better biofilm formation ability of ΔbrpL. Q  ...[more]

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