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Analysis of human leukocyte antigen (HLA) allotype-specific response in abacavir-exposed keratinocyte

ABSTRACT: Abacavir, a nucleoside reverse-transcriptase inhibitor used for the treatment of human immunodeficiency virus (HIV) infection, develops hypersensitivity in patients carrying HLA-B*57:01 allele through drug antigen presentation. We found that abacavir exposure induced HLA allotype-specific innate immune response in keratinocyte derived from HLA-B*57:01 transgenic mice. Therefore, the mechanism of the novel response was analyzed comprehensively.

ORGANISM(S): Mus musculus

PROVIDER: GSE110394 | GEO | 2018/03/01

REPOSITORIES: GEO

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