Browse
Submit Data
Databases
API
Help

Dataset Information

0 Views

0 Connections

0 Citations

0 Reanalyses

0 Downloads

Omics score: 0

Profiling in vivo Bone Lesion (IVBL) and Orthotopic tumors by Next Generation Sequencing

ABSTRACT: Based on RNA-seq, we performed transcriptomic profiling to examine the differences between Orthotopic and IVBL (in vivo bone lesion). We found Calcium signalling is upregulated in IVBL and correlated to the expression of gap junctions.

ORGANISM(S): Homo sapiens

PROVIDER: GSE110451 | GEO | 2018/10/16

REPOSITORIES: GEO

ACCESS DATA

Json Xml

Similar Datasets

Profiling in vivo Bone Lesion (IVBL) and Orthotopic tumors by Next Generation Sequencing

Project description:Profiling in vivo Bone Lesion (IVBL) and Orthotopic tumors by Next Generation Sequencing

| PRJNA433732 | ENA

Profiling in vivo Bone Lesion and ex vivo Bone-In-Culture Array Samples by Next-Generation Sequencing

Project description:Based on RNA-seq, we performed transcriptomic profiling to examine the similarities or differences between BICA (bone-in-culture array) and IVBL (in vivo bone lesion). CIBERSORT analysis reveals that the major local cellular components are comparable between BICA and IVBL, but differ dramatically in orthotopic tumors. Principle component analysis of human RNAs indicated that the transcriptomic profiles of cancer cells in BICA are more closely mimicking IVBL, as compared to cancer cells in 2D and in orthotopic tumors. These results provide transcriptome-wide evidence supporting BICA as a platform to mimic bone microenvironment.

2017-01-20 | GSE84114 | GEO

Expression data from the orthotopic tumors of MES-SA

Project description:The spontaneous pulmonary metastasis model of human uterine sarcoma was established using GFP-expressed MES-SA cells. Several sublines with different metastatic potentials were generated by in vivo passaging. We used microarrays to identify the metastatic-related genes using the orthotopic tumors with different metastatic potentials. Orthotopic transplanted uterine sarcoma were observed after 3 weeks post-transplantation and the xenografted tumor reached about 2000 mm3 in additional 3 weeks. After 6 weeks post-transplantation, the animals were sacrificed under isoflurane anesthesia, and the tumors were resected. The GFP-positive regions were collected using Leica MZ10F fluorescent stereomicroscope. This study compared the gene expression profiling between the orthotopic tumors with high (H)- and low (L)-metastatic potentials.

2014-12-08 | E-GEOD-63937 | biostudies-arrayexpress

RNA-seq of Sting overexpressing orthotopic pancreas tumors

Project description:RNA-seq of Sting overexpressing orthotopic pancreas tumors

| PRJEB46239 | ENA

Lesion Segregation

Project description:Liver Cancer Evolution - Lesion segregation

| PRJEB37808 | ENA

Gene Expression Analysis of 4T1 orthotopic tumors in PDGFRb-TK mice

Project description:Analysis of the gene expression level of 4T1 orthotopic tumors in mice with and without pericyte depletion.

2017-03-09 | GSE55785 | GEO

Glioblastoma Orthotopic Xenograft Transcriptome

Project description:Transcriptional profiling of glioblastoma orthotopic xenografts Descriptive experiment, comparison of 39 glioblastoma tumors as orthotopic xenografts

2012-07-10 | E-GEOD-38814 | biostudies-arrayexpress

Expression data from the orthotopic tumors of MES-SA

2014-12-08 | GSE63937 | GEO

Bearded lizard lesion investigation

Project description:Bearded lizard lesion investigation

| PRJEB25832 | ENA

Orthotopic KI tumors treated with vehicle or IRAK4 inhibitor CA-4948 for two weeks

Project description:We treated FVBN/J mice bearing orthotopic KI tumors with vehicle or CA-4948 for two weeks and performed bulk RNASeq to assess transcriptomic changes in the tumor

2022-12-31 | GSE197328 | GEO

OmicsDI is part of the ELIXIR infrastructure

OmicsDI is an Elixir interoperability service. Learn more ›

OmicsDI Databases

PRIDE
PeptideAtlas
MassIVE
JPOST Repository
Physiome Model Repository

EGA
EVA
ENA
LINCS
PAXDB
Cell Collective

MetaboLights
Metabolomics Workbench
MetabolomeExpress
GNPS
BioModels
FAIRDOMHub

ArrayExpress
dbGaP
ExpressionAtlas
GEO
NODE

Information

Databases
Help
API
Contact us
Code on GitHub
Terms of use
Submit Data