Genomics

Dataset Information

21

Glucagon contributes to liver zonation in mice


ABSTRACT: This SuperSeries is composed of the SubSeries listed below. Overall design: Refer to individual Series

INSTRUMENT(S): Illumina HiSeq 2500 (Mus musculus)

SUBMITTER: Yurong Xin  

PROVIDER: GSE110674 | GEO | 2018-03-01

SECONDARY ACCESSION(S): GSE110673 GSE110672

REPOSITORIES: GEO

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Publications

Glucagon contributes to liver zonation.

Cheng Xiping X   Kim Sun Y SY   Okamoto Haruka H   Xin Yurong Y   Yancopoulos George D GD   Murphy Andrew J AJ   Gromada Jesper J  

Proceedings of the National Academy of Sciences of the United States of America 20180319 17


Liver zonation characterizes the separation of metabolic pathways along the lobules and is required for optimal function. Wnt/β-catenin signaling controls metabolic zonation by activating genes in the perivenous hepatocytes, while suppressing genes in the periportal counterparts. We now demonstrate that glucagon opposes the actions of Wnt/β-catenin signaling on gene expression and metabolic zonation pattern. The effects were more pronounced in the periportal hepatocytes where 28% of all genes we  ...[more]

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