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Identifying a Novel Connection Between the Fungal Plasma Membrane and pH Sensing

ABSTRACT: To identify cellular processes similarly regulated by both Rim101 and Cdc50, we compared the transcriptomes of the rim101∆ and cdc50∆ strains against WT. We observed a partial overlap in the transcriptional perturbation shared by the mutant strains. Most notably, these data demonstrate a role for both Rim101 and Cdc50 in regulating the gene expression of membrane-associated proteins, including those involved in lipid bilayer composition and organization. Furthermore, this class of membrane-associated genes co-regulated by Rim101 and Cdc50 demonstrate similar expression changes in the two mutant strains in both direction and magnitude.

ORGANISM(S): Cryptococcus neoformans var. grubii H99

PROVIDER: GSE110723 | GEO | 2019/02/14

REPOSITORIES: GEO

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