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Differential Gene Expression of Human Mural Granulosa Cells in ICSI Patients Exposued to Low or High Environmental Levels of BDE-153 Quantified from Follicular Fluid [BDE-153 MURAL]

ABSTRACT: This study assessed the global gene-level expression of human mural granulosa cells.

ORGANISM(S): Homo sapiens

PROVIDER: GSE110922 | GEO | 2021/02/10

REPOSITORIES: GEO

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Differential Gene Expression of Human Mural Granulosa Cells in ICSI Patients Exposued to Low or High Environmental Levels of BDE-47 Quantified from Follicular Fluid [BDE-47 MURAL]

Project description:This study assessed the global gene-level expression of human mural granulosa cells.

2021-02-10 | GSE110919 | GEO

Differential Gene Expression of Human Cumulus Granulosa Cells in ICSI Patients Exposued to Low or High Environmental Levels of BDE-153 Quantified from Follicular Fluid [BDE-153 CUMULUS]

Project description:This study assessed the global gene-level expression of human cumulus granulosa cells.

2021-02-10 | GSE110921 | GEO

Differential Gene Expression of Human Mural Granulosa Cells in ICSI Patients Exposued to Low or High Environmental Levels of BDE-153 Quantified from Follicular Fluid [BDE-153 MURAL]

Project description:Differential Gene Expression of Human Mural Granulosa Cells in ICSI Patients Exposued to Low or High Environmental Levels of BDE-153 Quantified from Follicular Fluid [BDE-153 MURAL]

| PRJNA434818 | ENA

Differential Gene Expression of Human Mural Granulosa Cells in ICSI Patients Exposued to Low or High Environmental Levels of a Mixture of 10 PBDE Congeners Quantified in Follicular Fluid [10-PBDE_MURAL]

Project description:This study assessed the global gene-level expression of human mural granulosa cells.

2021-02-10 | GSE110917 | GEO

Differential Gene Expression of Human Mural Granulosa Cells in ICSI Patients Exposued to Low or High Environmental Levels of BDE-47 Quantified from Follicular Fluid [BDE-47 MURAL]

Project description:Differential Gene Expression of Human Mural Granulosa Cells in ICSI Patients Exposued to Low or High Environmental Levels of BDE-47 Quantified from Follicular Fluid [BDE-47 MURAL]

| PRJNA434815 | ENA

Differential Gene Expression of Human Cumulus Granulosa Cells in ICSI Patients Exposued to Low or High Environmental Levels of BDE-47 Quantified from Follicular Fluid [BDE-47 CUMULUS]

Project description:This study assessed the global gene-level expression of human cumulus granulosa cells.

2021-02-10 | GSE110918 | GEO

Differential Gene Expression of Human Cumulus Granulosa and Mural Granulosa Cells in ICSI Patients

Project description:Differential Gene Expression of Human Cumulus Granulosa and Mural Granulosa Cells in ICSI Patients

2021-02-10 | GSE110924 | GEO

Differential Gene Expression of Human Cumulus Granulosa Cells in ICSI Patients Exposued to Low or High Environmental Levels of BDE-153 Quantified from Follicular Fluid [BDE-153 CUMULUS]

Project description:Differential Gene Expression of Human Cumulus Granulosa Cells in ICSI Patients Exposued to Low or High Environmental Levels of BDE-153 Quantified from Follicular Fluid [BDE-153 CUMULUS]

| PRJNA434814 | ENA

Differential Gene Expression of Human Cumulus Granulosa Cells in ICSI Patients Exposued to Low or High Environmental Levels of a Mixture of 10 PBDE Congeners Quantified from Follicular Fluid [10-PBDE_CUMULUS]

Project description:This study assessed the global gene-level expression of human cumulus granulosa cells.

2021-02-10 | GSE110916 | GEO

Polybrominated Diphenyl Ethers in Human Follicular Fluid Dysregulate Mural and Cumulus Granulosa Cell Gene Expression.

Project description:Polybrominated diphenyl ethers (PBDEs), a major class of flame retardants incorporated into numerous consumer products, leach out into dust resulting in widespread exposure. There is evidence from in vitro and in vivo animal studies that PBDEs affect ovarian granulosa cell function and follicular development, yet human studies of their association with female infertility are inconclusive. Here, we tested the hypothesis that exposure to the PBDEs in follicular fluid is associated with dysregulation of gene expression in the mural and cumulus granulosa cells collected from women undergoing in vitro fertilization by intracytoplasmic sperm injection. The median concentration of the ∑ 10PBDEs detected in the follicular fluid samples (n = 37) was 15.04 pg/g wet weight. RNA microarray analyses revealed that many genes were differentially expressed in mural and cumulus granulosa cells. Highest vs lowest quartile exposure to the Σ 10PBDEs or to 2 predominant PBDE congeners, BDE-47 or BDE-153, was associated with significant effects on gene expression in both cell types. Mural granulosa cells were generally more sensitive to PBDE exposure compared to cumulus cells. Overall, gene expression changes associated with BDE-47 exposure were similar to those for ∑ 10PBDEs but distinct from those associated with BDE-153 exposure. Interestingly, exposure to BDE-47 and ∑ 10PBDEs activated the expression of genes in pathways that are important in innate immunity and inflammation. To the best of our knowledge, this is the first demonstration that exposure to these environmental chemicals is associated with the dysregulation of pathways that play an essential role in ovulation.

| S-EPMC7853176 | biostudies-literature

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