Cell type-dependent control of enhancer and p53 transcriptional activity by p63

ABSTRACT: In this work, we demonstrate that the p53-induced transcriptome is dependent on pre-establishment of cell type-dependent cis-regulatory networks. The epithelial-specific p53 transcriptome is strongly dependent on p63, which acts as a pioneer factor for epithelial-specific enhancers. These results suggest a broad mechanism for regulating the p53-dependent cellular response to stress through differential regulation of cis-regulatory elements and identify p63 as a direct and critical regulator of enhancer activity in epithelial cell types.

ORGANISM(S): Mus musculus Homo sapiens

PROVIDER: GSE111009 | GEO | 2019/02/11

REPOSITORIES: GEO