Study of sarcopenia in human muscle biopsies of elderly individuals, Singapore Sarcopenia Study

ABSTRACT: Purpose: The main goal of this study is to compare skeletal muscle transcriptome profilings derived from sarcopenic versus healthy subjects. Methods: We use high coverage RNA sequencing of human skeletal muscle biopsies to analyze genome-wide transcriptional changes in human sarcopenia benchmarked to healthy elderly controls. Results: Muscle transcriptomic profiles demonstrate a prominent signature of mitochondrial dysfunction in sarcopenic patients. Conclusions: Our study supports the fundamental role of mitochondrial dysfunction in driving pathological muscle and mobility decline in the elderly.

ORGANISM(S): Homo sapiens

PROVIDER: GSE111016 | GEO | 2019/11/14

REPOSITORIES: GEO