Cytosolic copper concentration modulates spore germination and secondary metabolism in Streptomyces coelicolor

ABSTRACT: We studied the influence of copper in physiological and morphological differentiation of Streptomyces coelicolor. We demonstrate differences in phenotype (germination, growth rate, antibiotic production) and genetic expression between a strain mutated at copper chaperone CopZ (SCO2730::Tn5062), the wild-type strain and a wild-type strain sporulated in a media with 80µM CuSO4. These differences are correlated with the cytosolic copper. Our results demonstrate a pleiotropic effect of copper modulating S. coelicolor development.

ORGANISM(S): Streptomyces coelicolor

PROVIDER: GSE111126 | GEO | 2018/12/31

REPOSITORIES: GEO