Impact of mIHF on gene expression

ABSTRACT: mIHF is a possible nucleoid associated protein. Its effect on gene regulation remains unknown. We performed an RNA-seq analysis of the mihF conditional knock-down mutant in Mycobacterium tuberculosis. We show that mihF is essential for in vitro growth and that depeltion of mIHF results in deregulation of a large number of genes. Notably, the most downregulated gene was the espACD operon, which is necessary for secretion of M. tuberculosis main virulence factor EsxA.

ORGANISM(S): Mycobacterium tuberculosis

PROVIDER: GSE111193 | GEO | 2018/02/28

REPOSITORIES: GEO