Dataset Information


Histone H3 T11 phosphorylation by Sch9 and CK2 regulates lifespan by controlling the nutritional stress response [ChIP-seq]

ABSTRACT: We report the changes of Histone H3 T11 phosphorylation (H3pT11) signal upon nutritional stress (YP with 3% glycerol). Overall design: Two replicates each of H3pT11 ChIP in YPD (YP media with 2% glucose) and YPglycerol (YP with 3% glycerol) as well as corresponding H3 IP samples (used as controls).

INSTRUMENT(S): Illumina HiSeq 2500 (Saccharomyces cerevisiae)

ORGANISM(S): Saccharomyces cerevisiae  

SUBMITTER: Madelaine Gogol 

PROVIDER: GSE111218 | GEO | 2018-06-26


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Histone H3 threonine 11 phosphorylation by Sch9 and CK2 regulates chronological lifespan by controlling the nutritional stress response.

Oh Seunghee S   Suganuma Tamaki T   Gogol Madelaine M MM   Workman Jerry L JL  

eLife 20180625

Upon nutritional stress, the metabolic status of cells is changed by nutrient signaling pathways to ensure survival. Altered metabolism by nutrient signaling pathways has been suggested to influence cellular lifespan. However, it remains unclear how chromatin regulation is involved in this process. Here, we found that histone H3 threonine 11 phosphorylation (H3pT11) functions as a marker for nutritional stress and aging. Sch9 and CK2 kinases cooperatively regulate H3pT11 under stress conditions.  ...[more]

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