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Comparison of P18 mouse epidermis from K5-FGFR1/FGFR2 knockout and wild-type mice

ABSTRACT: Fibroblast growth factors (FGFs) are master regulators of organogenesis and tissue homeostasis. We generated FGF receptor (FGFR)-deficient mice to unravel their functions in the skin. These mice revealed interesting phenotypic abnormalities, including loss of skin appendages, cutaneous inflammation, keratinocyte hyperproliferation, and acanthosis. To gain insight into the underlying molecular mechanisms, we wanted to identify genes, which are differentially expressed in the skin of wild-type and mutant mice before the onset of phenotypic alterations.

ORGANISM(S): Mus musculus

PROVIDER: GSE111274 | GEO | 2020/06/23

REPOSITORIES: GEO

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Comparison of P18 mouse epidermis from K5-FGFR1/FGFR2 knockout and wild-type mice

Project description:Comparison of P18 mouse epidermis from K5-FGFR1/FGFR2 knockout and wild-type mice

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