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Macrophage microRNA-150 promotes pathological angiogenesis as seen in age-related macular degeneration: part I

ABSTRACT: Macrophage aging is pathogenic in numerous age-associated diseases, including age-related macular degeneration. The purpose of this experiment was to profile microRNA expression in young and aged macrophages at baseline and in response to oxLDL and acLDL.

ORGANISM(S): synthetic construct Mus musculus

PROVIDER: GSE111304 | GEO | 2018/04/05

REPOSITORIES: GEO

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Macrophage microRNA-150 promotes pathological angiogenesis as seen in age-related macular degeneration

Project description:Macrophage microRNA-150 promotes pathological angiogenesis as seen in age-related macular degeneration

| PRJNA436587 | ENA

Macrophage microRNA-150 promotes pathological angiogenesis as seen in age-related macular degeneration

Project description:This SuperSeries is composed of the SubSeries listed below.

2018-04-05 | GSE111323 | GEO

Macrophage microRNA-150 promotes pathological angiogenesis as seen in age-related macular degeneration.

Project description: Not available

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Macrophage microRNA-150 promotes pathological angiogenesis as seen in age-related macular degeneration: part II

Project description:We identified that microRNA-150 is upregulated in aged macrophages of diverse origins and therefore may mechanistically skew them towards a disease-promoting phenotype. The purpose of this experiment was to identify how the murine transcriptome changes with microRNA-150 overexpression.

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Macrophage microRNA-150 promotes pathological angiogenesis as seen in age-related macular degeneration: part I

Project description:Macrophage microRNA-150 promotes pathological angiogenesis as seen in age-related macular degeneration: part I

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Macular Degeneration

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