DNA methylation inhibition attenuates pressure overload-induced cardiac hypertrophy in rats

ABSTRACT: Inhibitors of DNA methyl transferase (DNMT) might be useful for treating cardiac hypertrophy by preventing de novo methylation and reduced transcription of anti-hypertrophic genes. This approach had been tested, but without a detailed phenotypic and methylation analysis. Here, we subjected rats to pressure overload and treatment with the DNMT inhibitor N-phthalyl-L-tryptophan (RG108) and analysed DNA methylation by cardiomyocyte (CM)-specific reduced representation bisulphite sequencing (RRBS).

ORGANISM(S): Rattus norvegicus

PROVIDER: GSE111513 | GEO | 2019/03/07

REPOSITORIES: GEO