A Retinoic Acid-dependent Stroma-Leukemia Crosstalk Promotes Chronic Lymphocytic Leukemia Progression [RNA-seq]

ABSTRACT: In B-cell chronic lymphocytic leukemia (CLL), the non-hematopoietic stromal microenvironment plays a critical role in promoting tumor cell recruitment, activation, survival and expansion. Using the Eμ-TCL1 mouse model, we demonstrate that leukemic cells induce the activation of retinoid acid synthesis and signaling in stromal cells of the lymphoid microenvironment.

OTHER RELATED OMICS DATASETS IN: PRJNA437128 PRJNA437512 PRJNA437532

ORGANISM(S): Mus musculus

PROVIDER: GSE111612 | GEO | 2018/05/09

REPOSITORIES: GEO