Deletion of Lats 1 and 2 in mouse pancreatic acinar cells

ABSTRACT: Mice with adult pancreatic acinar cell–specific deletion of Lats1&2 genes by using CreER/LoxP were generated. Pancreata were collected and profiled using RNA-seq. The RNA-sequencing data identified upregulation of pro-inflammatory and pro-fibrotic genes in Lats1&2 null pancreata, which may play important roles in stimulating PSC activation and promoting pancreatic fibrosis.

ORGANISM(S): Mus musculus

PROVIDER: GSE111640 | GEO | 2019/07/26

REPOSITORIES: GEO