Genomics

Dataset Information

0

The LINC01138 Drives Malignancies via Activating Arginine Methyltransferase 5 in Hepatocellular Carcinoma


ABSTRACT: Our study have demonstrated LINC01138 acts as an oncogenic driver that promotes cell proliferation, tumourigenicity, tumour invasion and metastasis through physically interacting with Arginine Methyltransferase 5 (PRMT5) in HCC cells. In order to investigate the related signaling pathways regulated by LINC01138 or PRMT5, we performed the unbiased transcriptome profiling using high-throughput RNA sequencing in SMMC-7721 cells transfected with si-LINC01138 or si-PRMT5. Here we showed the LINC01138/PRMT5 axis is an ideal therapeutic target for HCC treatment.

ORGANISM(S): Homo sapiens

PROVIDER: GSE111655 | GEO | 2018/03/11

REPOSITORIES: GEO

Similar Datasets

2015-08-27 | GSE72411 | GEO
| E-GEOD-44094 | biostudies-arrayexpress
| E-GEOD-72411 | biostudies-arrayexpress
| E-GEOD-57786 | biostudies-arrayexpress
| E-GEOD-52554 | biostudies-arrayexpress
2017-11-24 | GSE63599 | GEO
2014-02-08 | GSE54798 | GEO
| E-GEOD-65210 | biostudies-arrayexpress
2015-04-07 | GSE67594 | GEO
2015-01-13 | GSE64890 | GEO