RET-mediated autophagy suppression as targetable co-dependence in acute myeloid leukemia

ABSTRACT: Many cases of acute myeloid leukemia (AML) are associated with mutational activation of RTKs such as FLT3. However, RTK inhibitors have limited clinical efficacy as single agents, indicating that AML is driven by concomitant activation of different signaling molecules. We used a functional genomic approach to identify RET, encoding an RTK not previously implicated in AML, as essential gene in different AML subtypes, and observed that RET-dependent AML cells show activation of RET signaling via ARTN/GFRA3 and NRTN/GFRA2 ligand/co-receptor complexes.

ORGANISM(S): Homo sapiens

PROVIDER: GSE111678 | GEO | 2018/12/21

REPOSITORIES: GEO