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Impact of chorioamnionitis exposure on neonatal monocyte H3K4me3 patterning

ABSTRACT: We sought to determine the impact of chorioamnionitis exposure on the neonatal monocyte H3K4me3 histone modification landscape over the course of fetal and neonatal immune system development using ChIP-seq. H3K4me3 ChIP-seq was performed on umbilical cord blood purified CD14+ monocytes from healthy and chorioamnionitis-exposed extremely preterm neonates (under 30 weeks gestation), late preterm neonates (30-36 weeks gestation), and term neonates (37+ weeks gestation).

ORGANISM(S): Homo sapiens

PROVIDER: GSE111873 | GEO | 2018/08/01

REPOSITORIES: GEO

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