Genomics

Dataset Information

6

Rheumatoid arthritis associated DNA methylation sites in peripheral blood mononuclear cells


ABSTRACT: Genome wide DNA methylation profiling of rheumatoid arthritis (RA) patients and healthy controls. The Illumina Infinium 450k Human DNA methylation Beadchip was used to obtain DNA methylation profiles in peripheral blood mononuclear cells (PBMCs). Samples included 25 RA patients and 18 healthy controls. Overall design: To identify more rheumatoid arthritis (RA) associated DNA methylation sites and comprehensively understand their underlying pathologic mechanism, we compared the Illumina Infinium 450k Human DNA methylation microarray data from PBMCs of 25 RA patients with that of 18 healthy controls.

INSTRUMENT(S): Illumina HumanMethylation450 BeadChip (HumanMethylation450_15017482)

SUBMITTER: Xingbo Mo  

PROVIDER: GSE111942 | GEO | 2018-10-14

REPOSITORIES: GEO

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Publications


<h4>Objectives</h4>To identify novel DNA methylation sites significant for rheumatoid arthritis (RA) and comprehensively understand their underlying pathological mechanism.<h4>Methods</h4>We performed (1) genome-wide DNA methylation and mRNA expression profiling in peripheral blood mononuclear cells from RA patients and health controls; (2) correlation analysis and causal inference tests for DNA methylation and mRNA expression data; (3) differential methylation genes regulatory network construct  ...[more]

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