Ontology highlight
ABSTRACT:
INSTRUMENT(S): Illumina HiSeq 2500 (Mus musculus)
SUBMITTER: Kristen Kokkonen-Simon
PROVIDER: GSE112056 | GEO | 2018-08-09
SECONDARY ACCESSION(S): GSE112054 GSE112055S-EPMC6129132
REPOSITORIES: GEO
JCI insight 20180809 15
MicroRNAs (miRs) posttranscriptionally regulate mRNA and its translation into protein, and are considered master controllers of genes modulating normal physiology and disease. There is growing interest in how miRs change with drug treatment, and leveraging this for precision guided therapy. Here we contrast 2 closely related therapies, inhibitors of phosphodiesterase type 5 or type 9 (PDE5-I, PDE9-I), given to mice subjected to sustained cardiac pressure overload (PO). Both inhibitors augment cy ...[more]