Browse
Submit Data
Databases
API
Help

Dataset Information

0 Views

0 Connections

0 Citations

0 Reanalyses

0 Downloads

Omics score: 0

Risk SNPs mediated promoter-enhancer switching promotes prostate cancer progression through lncRNA PCAT19 (ChIP-seq data set)

ABSTRACT: To determine the binding of H3K4me1 and H3K4me3 to PCAT19 locus, we performed ChIP-seq in 22Rv1 cells.

ORGANISM(S): Homo sapiens

PROVIDER: GSE112120 | GEO | 2019/03/11

REPOSITORIES: GEO

ACCESS DATA

Json Xml

Similar Datasets

Risk SNPs mediated promoter-enhancer switching promotes prostate cancer progression through lncRNA PCAT19

Project description:This SuperSeries is composed of the SubSeries listed below.

2019-03-11 | GSE112164 | GEO

Risk SNPs mediated promoter-enhancer switching promotes prostate cancer progression through lncRNA PCAT19 (RNA-seq data sets)

Project description:To determine the functional mechanisms of PCAT19-long isoform and HNRNPAB, we conducted siRNA knockdown RNA-sequencing in prostate cancer cell line V16A.

2019-03-11 | GSE106774 | GEO

Risk SNPs mediated promoter-enhancer switching promotes prostate cancer progression through lncRNA PCAT19

Project description:Risk SNPs mediated promoter-enhancer switching promotes prostate cancer progression through lncRNA PCAT19

| PRJNA442593 | ENA

Risk SNPs mediated promoter-enhancer switching promotes prostate cancer progression through lncRNA PCAT19 (ChIP-seq data set)

Project description:Risk SNPs mediated promoter-enhancer switching promotes prostate cancer progression through lncRNA PCAT19 (ChIP-seq data set)

| PRJNA439377 | ENA

Risk SNPs mediated promoter-enhancer switching promotes prostate cancer progression through lncRNA PCAT19 (RNA-seq data sets)

Project description:Risk SNPs mediated promoter-enhancer switching promotes prostate cancer progression through lncRNA PCAT19 (RNA-seq data sets)

| PRJNA417969 | ENA

The association of lncRNA SNPs and SNPs-environment interactions based on GWAS with HBV-related HCC risk and progression.

Project description: Not available

| S-EPMC8077159 | biostudies-literature

Risk SNP-mediated enhancer-promoter interaction drives keloid through lncRNA DEIK

Project description:Genetics is a major factor for keloid predisposition and the genome-wide association study (GWAS) has identified a single nucleotide polymorphism (SNP) rs873549 at 1q41 as a susceptibility locus. However, the functional significance of this locus in keloid pathogenesis remains elusive. Here, we found that rs1348270, an enhancer located SNP in strong linkage disequilibrium with rs873549, mediated looping with the promoter of a lncRNA DEIK (Down Expressed In Keloids, formerly RP11-400N13.1). The risk variant was associated with decreased enhancer-promoter interaction and DEIK expression. Mechanistically, downregulation of DEIK increased the expression of collagens and chondrocyte and osteocyte associated genes such as POSTN and COMP through upregulating BMP2. Furthermore, correlation analysis revealed that DEIK expression was inversely correlated with BMP2, POSTN and COMP expression in keloid and normal fibroblasts. These findings uncover new mechanisms underlying genetic factor-mediated keloid predisposition and identify potential targets for keloid therapies.

2022-05-08 | GSE202293 | GEO

Super-Enhancer LncRNA LINC00162 Promotes Progression of Bladder Cancer.

Project description: Not available

| S-EPMC7736918 | biostudies-literature

SNPs in lncRNA Regions and Breast Cancer Risk.

Project description: Not available

| S-EPMC7340126 | biostudies-literature

A Dinucleotide-barcode reporter system and application in dissecting the causal rule of regulatory risk SNPs

Project description:We adapted the DiR barcode-based parallel reporter assay systems strategy to systematically identify the SNPs that affect gene expression by modulating activities of regulatory elements. Among 293 SNPs linked with GWAS-identified prostate cancer-risk SNPs, we found 32, 9, and 11 regulatory SNPs in 22Rv1, PC-3, and LNCaP cells. Further mechanism study indicates that one SNP regulates gene expression in prostate cancer malignancy. The DiR system has great potential to advance the functional study of risk SNPs that have associations with polygenic diseases. Our findings hold great promise in benefiting prostate cancer patients with prognostic prediction.

2021-01-30 | GSE165765 | GEO

OmicsDI is part of the ELIXIR infrastructure

OmicsDI is an Elixir interoperability service. Learn more ›

OmicsDI Databases

PRIDE
PeptideAtlas
MassIVE
JPOST Repository
Physiome Model Repository

EGA
EVA
ENA
LINCS
PAXDB
Cell Collective

MetaboLights
Metabolomics Workbench
MetabolomeExpress
GNPS
BioModels
FAIRDOMHub

ArrayExpress
dbGaP
ExpressionAtlas
GEO
NODE

Information

Databases
Help
API
Contact us
Code on GitHub
Terms of use
Submit Data