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Transcriptional changes of influenza A/Hong Kong/1/68-H3N2 (HK68) infected A549 lung epithelial cells

ABSTRACT: Typically viral infections make the host more susceptible to subsequent bacterial infections by mechanisms that are incompletely defined. To identify host changes that occur in response to HK68 infection, gene expression of A549 lung epithelial cells were identified. Changes included an increase in transcripts encoding proteins with fibronectin-type III (FnIII) domains, such as fibronectin (Fn), tenascin N (TNN), and tenascin C (TNC). Results provide insight on the host response to IAV infection, including the production of a variety of ECM proteins, which can create an environment rich in host ligands for bacteria adherence

ORGANISM(S): Homo sapiens

PROVIDER: GSE112215 | GEO | 2018/12/25

REPOSITORIES: GEO

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Transcriptomic characterization of the novel avian-origin influenza A (H7N9) virus: specific and intermediate host-response between avian (H5N1 and H7N7) and human (H3N2) viruses.

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Homo sapiens

Project description:Host response to IAV infections in human patients

| PRJNA395232 | ENA

Tumor-associated macrophages promote ovarian cancer cell migration by secreting transforming growth factor beta induced (TGFBI) and tenascin C

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