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KH-type splicing regulatory protein controls colorectal cancer cell growth and modulates the tumor microenvironment

ABSTRACT: KH-type splicing regulatory protein (KHSRP) is a multifunctional nucleic acid binding protein. KHSRP regulates transcription, mRNA decay and translation, and miRNA biogenesis that influence distinct functions associated with cancer cell biology, such as inflammation and cell-fate determination. Our study uncovered novel mechanistic-based data on the tumor-promoting effects of KHSRP in colorectal cancer. We used microarrays to detail changes in gene expression upon specific knockdown of KHSRP in SW480 cells

ORGANISM(S): Homo sapiens

PROVIDER: GSE112329 | GEO | 2019/05/08

REPOSITORIES: GEO

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