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Expression data from Rb family (Rb, p130 and p107) deficient Hematopoietic stem Cells

ABSTRACT: Loss of Rb family in HSCs results in a severe phenotype, such as enhanced proliferation and increase in stem cell number. In addition, HSCs were higly mobilized but failed to transplant. Rb family deficient mice rapidly exhibit a myeloproliferative disease with eosinophilic characteristics. Meanwhile, the lymphoid compartment was severely decreased, due to high apoptotic activity in this lineage. Keywords: unpaired WT versus Rb family deficient KLS

ORGANISM(S): Mus musculus

PROVIDER: GSE11253 | GEO | 2008/04/25

SECONDARY ACCESSION(S): PRJNA106763

REPOSITORIES: GEO

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Transcription profiling of mouse Rb, p130 and p107 deficient hematopoietic stem Cells

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