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Spop restrains inflammation-induced emergency hematopoiesis by targeting MyD88 [Bulk RNA-Seq]

ABSTRACT: examination of the transcriptional profile of LSK and neutrophils (L6G+)

ORGANISM(S): Mus musculus

PROVIDER: GSE112538 | GEO | 2019/08/12

REPOSITORIES: GEO

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Spop restrains inflammation-induced emergency hematopoiesis by targeting MyD88 [scRNA-Seq]

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Spop restrains inflammation-induced emergency hematopoiesis by targeting MyD88

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Spop restrains inflammation-induced emergency hematopoiesis by targeting MyD88

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Spop restrains inflammation-induced emergency hematopoiesis by targeting MyD88

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Spop restrains inflammation-induced emergency hematopoiesis by targeting MyD88 [Bulk RNA-Seq]

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Dynamic DNA methylation reveals novel cis-regulatory elements in murine hematopoiesis

Project description:Genome wide DNA methylation profiling of 9 different cell types of the murine hematopoietic system. The samples comprise FACS-sorted biological triplicates of hematopoietic stem and progenitor cells (LSK, CMP, GMP, MEP) and terminally differentiated immune cells (monocytes, neutrophils, CD4+ T-cells, CD8+ T-cells, B-cells). Additionally, bone marrow of CD45.1 (B6.SJL-Ptprca Pepcb/BoyCrl) and CD45.2 (C57BL/6J) mice as well as JAK2-V617F mutant mice was analyzed. The Illumina Infinium Mouse Methylation BeadChip was used to generate DNA methylation profiles across approximately 285,000 CpGs in these samples.

2022-11-08 | GSE201923 | GEO

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