The gene expression profiles of antigen-primed wildtype and Ddit3-/- CD8 Pmel T cells

ABSTRACT: T cell undergoes ER stress during regular priming which may lead to T cell dysfunction in cancer. ER stress downstream sensor Chop (encoded by Ddit3 gene) negatively regulates CD8 T cell function and cytotoxicity. Because Chop is a C/EBP homologous transcription factor, we sorted antigen-primed wildtype or ddit3-/- Pmel CD8 T cells perform RNA-seq and gene expression profile analysis.

ORGANISM(S): Mus musculus

PROVIDER: GSE112823 | GEO | 2019/04/02

REPOSITORIES: GEO