Impact of Dnm3os silencing on bleomycin-induced lung fibrosis

ABSTRACT: To assess the impact of Dnm3os silencing on lung fibrogenesis, anti-Dnm3os gapmers (5mg/kg, 2 distinct designs: GP DNM3OS-1 and GP DNM3OS-3) or control gapmer (5mg/kg, GP Ctrl) formulated for in vivo delivery was instilled intratracheally 4 days and 2 days before intratracheal administration of bleomycin (1 unit/kg) or PBS as well as 4 days after bleomycin or PBS treatment.

ORGANISM(S): Mus musculus

PROVIDER: GSE112827 | GEO | 2019/04/11

REPOSITORIES: GEO