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Expression data from SKOV3 KO1#_Vector and SKOV3 KO1#_MED12 rescued cells

ABSTRACT: Epithelial ovarian cancer (EOC) is the leading cause of death among all gynecological malignancies due to high rate of disease relapse. Disease relapse in cancer patients after clinical remission are often referred to tumor dormancy. Here we identify the RNA polymerase II transcriptional Mediator subunit 12 (MED12) as an important molecular regulator of tumor dormancy. We found that MED12 knock-out (KO) could induce dormancy of EOC cells in vitro and in vivo. Mechanistically, microarray analysis showed that MED12 KO decreased the expression of EGFR. Hierarchical cluster assays of the differentially expressed genes between SKOV3 KO1#_Vector and SKOV3 KO1#_MED12 cells

ORGANISM(S): Homo sapiens

PROVIDER: GSE112887 | GEO | 2018/04/10

REPOSITORIES: GEO

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Expression data from WT and MED12 KO SKOV3 and HO8910 cells

Project description:Epithelial ovarian cancer (EOC) is the leading cause of death among all gynecological malignancies due to high rate of disease relapse. Disease relapse in cancer patients after clinical remission are often referred to tumor dormancy. Here we identify the RNA polymerase II transcriptional Mediator subunit 12 (MED12) as an important molecular regulator of tumor dormancy. We found that MED12 knock-out (KO) could induce dormancy of EOC cells in vitro and in vivo. Mechanistically, microarray analysis showed that MED12 KO decreased the expression of EGFR. Hierarchical cluster assays of the differentially expressed genes between MED12 WT and KO single clones of SKOV3 and HO8910 cells.

2018-04-10 | GSE112888 | GEO

Expression data from SKOV3 KO1#_Vector and SKOV3 KO1#_MED12 rescued cells

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Expression data from WT and MED12 KO SKOV3 and HO8910 cells

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gene expression when silencing RBMS3 in ovarain cancer cell line SKOV3

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