Poly(GR) impairs protein translation and stress granule dynamics in C9orf72-associated frontotemporal dementia and amyotrophic lateral sclerosis

ABSTRACT: We show that GFP-(GR)100-expressing mice developed age-dependent neurodegeneration, brain atrophy, as well as motor and memory impairments through the accumulation of diffuse, cytoplasmic poly(GR).

ORGANISM(S): Mus musculus

PROVIDER: GSE112931 | GEO | 2019/02/04

REPOSITORIES: GEO