NOTCH-mediated non-cell autonomous regulation of chromatin structure during senescence [RNA-Seq]

ABSTRACT: We decribe the accessible chormatin landscape in RAS-induced (RIS) and NOTCH induced senescence (NIS) using ATAC-seq. By expressing active NOTCH (N1ICD) in the context of RIS, we find that N1ICD antagonises the formation of accessible regions in RIS. By performing co-cultures, we demonstrate that cells expressing a NOTCH1 ligand, JAGGED1, can antagonise the formation of RIS specific accessible regions.

ORGANISM(S): Homo sapiens

PROVIDER: GSE113060 | GEO | 2018/04/24

REPOSITORIES: GEO