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MicroRNA array analysis of Pbx1-deficient and control murine HSCs and Flk2neg MPPs

ABSTRACT: The balance of self-renewal and differentiation is crucial to ensure the homeostasis of the hematopoietic system, and is a key hallmark of hematopoietic stem cells (HSCs); however, the underlying molecular pathways are not completely understood, including the role of micro-RNAs. To assess micro-RNA contributions, we performed micro-RNA profiling of HSCs and their immediate downstream progeny multi-potent progenitors (MPPs) from wild type control and Pbx1-conditional knockout mice, whose HSCs display a profound self-renewal defect.

ORGANISM(S): Mus musculus

PROVIDER: GSE113062 | GEO | 2019/04/01

REPOSITORIES: GEO

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