Effects of the RNA Exosome on damage induced small RNAs in the 28S ribosomal locus

ABSTRACT: The repair of DNA double strand breaks (DSBs) has recently been shown to depend not only on protein function but also on RNA. In particular, the processing of a long damage-induced RNA into small damage induced RNAs (diRNAs) has been a focus of interest. Given that the RNA exosome has been shown in Drosophila and human cells to participate in DSB repair, we investigated whether the catalytic components EXOSC10 and DIS3 have a function in diRNA biogenesis in human cells.

ORGANISM(S): Homo sapiens

PROVIDER: GSE113109 | GEO | 2019/04/10

REPOSITORIES: GEO