Transcriptomics,Genomics

Dataset Information

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Targeted degradation of BRD9 reverses oncogenic gene expression in synovial sarcoma [RNA-seq]


ABSTRACT: We used a CRISPR-based screening approach to identify functional vulnerabilities in pediatric sarcoma cell types, identifying BRD9 as an important dependency in synovial sarcoma cells. Overall design: RNA-seq in synovial cells treated with dBRD9A or DMSO for 6hrs, or the same cells expressing control (Renilla) or SS18-SSX1 specific shRNAs.

INSTRUMENT(S): Illumina NextSeq 500 (Homo sapiens)

SUBMITTER: Gerard L Brien  

PROVIDER: GSE113227 | GEO | 2018-11-01

REPOSITORIES: GEO

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