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Delayed colostrum feeding influences ileum transcriptome profile in neonatal calves

ABSTRACT: Our study would like to explore the different colostrum feeding time treatment, as well as the influence of host-microbial interaction on transcriptome profile and enriched functions of the two day old dairy calves.

ORGANISM(S): Bos taurus

PROVIDER: GSE113331 | GEO | 2021/03/05

REPOSITORIES: GEO

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Genome wide transcriptome analysis provides bases on colonic mucosal immune system development in neonatal calves affected by colostrum feeding strategies in neonatal calves

Project description:Delivery of colostrum within the first several hours after birth is vital for establishing successful passive immunity in neonatal dairy calves. However, it is unclear whether the difference in colostrum feeding strategy can affect the development of the calf gastrointestinal tract. The aim of this study was to evaluate the effect of colostrum feeding time within the first 12 h after birth on the colonic mucosal immune system in neonatal calves using a genome wide transcriptome analysis.RNA sequencing based transcriptome analysis of colon tissues collected from twenty-seven male Holstein calves which were randomly assigned to one of three colostrum feeding strategies (immediately after birth (TRT0); 6 h after birth (TRT6); 12 h after birth (TRT12)) and were euthanized at 51 h of age detected 15935 ± 210, 15332 ± 415, and 15539 ± 440 expressed genes in groups, respectively. The core transcriptome of the colon in dairy calves included 12,678 genes, with enriched “cellular process” and “metabolic process” as the top three biological functions. Expression of 802 immune related genes were detected in the colon tissue. Principal component analysis of the transcriptomes did not display a clear separation by colostrum feeding strategy, and differential abundance analyses showed no significant difference in the expression of immune related genes among the treatments.Transcriptome analysis indicates that the development of the colonic mucosal immune system in neonatal calves may be independent of the timing of initial colostrum meal within 12 h after birth.

2018-08-09 | GSE113264 | GEO

Delayed colostrum feeding influences ileum transcriptome profile in neonatal calves

Project description:Delayed colostrum feeding influences ileum transcriptome profile in neonatal calves

| PRJNA450829 | ENA

Blood immune transcriptome analysis of artificially fed dairy calves and naturally suckled beef calves from birth to 7 days of age

Project description:The aim of the overall study was to investigate the development of immune competence in artificially reared dairy calves and in two breeds of naturally suckled beef calves over the first 168h of life. Dairy calves were fed 5% total body weight of colostrum, with beef calves monitored to ensure natural ingestion of colostrum. Blood samples were taken from all calves at 24h 48h 72h and 168h, and analysed for alterations to immunes genes.

2018-10-29 | GSE114432 | GEO

Host innate immune responses and microbiome profile of neonatal calves challenged with Cryptosporidium parvum and the effect of bovine colostrum supplementation

Project description:Calves are highly susceptible to gastrointestinal infection with Cryptosporidium parvum (C. parvum), which can result in watery diarrhea and eventually death or impaired development. With little to no effective therapeutics, understanding the host’s microbiota and pathogen interaction at the mucosal immune system has been critical to identify and test novel control strategies. We used an experimental model of C. parvum challenge in neonatal calves to describe the clinical signs and mucosal innate immune and microbiota hallmarks in the ileum and colon during cryptosporidiosis and investigated the impact of supplemental colostrum feeding on C. parvum infection. The C. parvum challenged calves experienced clinical signs including pyrexia and diarrhea 5 days post challenge. These calves showed ulcerative neutrophil ileitis with a proteomic signature driven by inflammatory effectors, including reactive oxygen species and myeloperoxidases. Colitis was also noticed with an aggravated mucin barrier depletion and lack of full filled mucin granule in goblet cells. The C. parvum challenged calves also displayed a pronounced dysbiosis with a high prevalence of Clostridium species (spp.) and number of exotoxins, adherence factors, and secretion systems related to Clostridium spp. and other enteropathogens, including Campylobacter spp., Escherichia sp., Shigella spp., and Listeria spp. Daily supplementation with a high-quality bovine colostrum product mitigated some of the clinical signs and modulated the gut immune response and concomitant microbiota to a pattern more similar to that of healthy unchallenged calves.

2023-04-27 | PXD040269 | Pride

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Project description:Acidification of colostrum affects the fecal microbiota of pre-weaned dairy calves

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Genome wide transcriptome analysis provides bases on colonic mucosal immune system development in neonatal calves affected by colostrum feeding strategies in neonatal calves

Project description:Genome wide transcriptome analysis provides bases on colonic mucosal immune system development in neonatal calves affected by colostrum feeding strategies in neonatal calves

| PRJNA450608 | ENA

Transcriptomic analysis of adipose and muscle of dairy calves supplemented with 5-hydroxytryptophan

Project description:Serotonin is a monoamine that regulates processes such as energy balance and immune function. Manipulating this pathway in growing dairy calves could promote growth and development by modulating functions and signaling pathways within key organs. In this study, we characterized the adipose and muscle transcriptome of pre-weaned calves with increased serotonin bioavailability through the elucidation of differentially expressed genes.

2020-06-05 | GSE151781 | GEO

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Project description:dairy calves feces Raw sequence reads

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Early milk-feeding regimes in calves exert long-term influence on the development of ovarian granulosa cells

Project description:We analysed effects of different feeding regimes of milk replacer (MR) during rearing on ovarian physiology with specific emphasis on the numbers of granulosa cells (GCs) as well as gene expression characteristics in GCs at the age of puberty onset. Animals of the 20% feeding group had a significantly higher body weight, but the proportion of animals having a corpus luteum at the time of slaughter was not different between groups, suggesting a similar onset of puberty. Calves of the 10% group showed a constant granulosa cell count regardless of the number of follicles (r = 0.23) whereas in the 20% group increasing numbers of GCs were detected with a higher follicle count (r = 0.71). The mRNA microarray analysis revealed a total of 557 differentially expressed genes in GCs (fold change > |1.5| and p<0.05). Among the top downregulated genes were OAS1X, MX2 and OAS1Z, whereas the top upregulated genes were BOLA, XCL1 and MT1E, which are known to be regulated by interferon. Subsequent signaling pathway analysis revealed the involvement of several immune response mechanisms in accordance with a number of interferons as upstream regulators. The results indicate that the plane of MR feeding in early life have an impact on the number and physiology of GCs later in life. This might influence the overall reproductive life initiated by the onset of puberty in cattle. In addition, the observed alterations in GCs of calves fed less MR might be a consequence of interferon regulated immunological pathways.

2023-08-25 | GSE216927 | GEO

LC-MS/MS Data of Skeletal Muscle and Plasma of Preruminant Calves fed with Leucine and Threonine Supplemented Diets

Project description:The objective of present work is to use foodomics approaches in calves’ skeletal muscle and plasma to fully assess the effects of the supplementations of leucine and threonine in the MR during preweaning period (5.6 days to 53.6 days) under the hypothesis that AA supplementation will modify the energy metabolism, especially of the muscle tissue. This study extends our understanding on the metabolism in dairy calves and help to optimize their nutritional status.

2020-02-17 | PXD016098 | Pride

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