Conditional DICER1 knockout hESCs

ABSTRACT: We report the generation and characterization of DICER1-deficient hESCs. We uncover an unexpected requirement for DICER1 as well as essential pro-survival roles of members of the mir-302- 367 and mir-371- 373 clusters in hESCs. Our work provides a robust platform for interrogating microRNA function in hESC and differentiation.

ORGANISM(S): Homo sapiens

PROVIDER: GSE113375 | GEO | 2018/08/01

REPOSITORIES: GEO