Ontology highlight
ABSTRACT:
INSTRUMENT(S): Illumina NextSeq 500 (Mus musculus)
ORGANISM(S): Mus musculus
SUBMITTER: Ido Amit
PROVIDER: GSE113494 | GEO | 2018-06-19
REPOSITORIES: GEO
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GSE113494_crispseq_count.txt.gz | Txt |
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Giladi Amir A Paul Franziska F Herzog Yoni Y Lubling Yaniv Y Weiner Assaf A Yofe Ido I Jaitin Diego D Cabezas-Wallscheid Nina N Dress Regine R Ginhoux Florent F Trumpp Andreas A Tanay Amos A Amit Ido I
Nature cell biology 20180618 7
The dynamics of haematopoietic stem cell differentiation and the hierarchy of oligopotent stem cells in the bone marrow remain controversial. Here we dissect haematopoietic progenitor populations at single cell resolution, deriving an unbiased reference model of transcriptional states in normal and perturbed murine bone marrow. We define the signature of the naive haematopoietic stem cell and find a continuum of core progenitor states. Core cell populations mix transcription of pre-myeloid and p ...[more]