Paneth cells acquire multi-potency upon Notch activation after irradiation

ABSTRACT: In murine models, we find that irradiation of Paneth cells caused a gain of a stem cell-like transcriptome and induced activation of the Notch signaling pathway. This study documents plasticity by Paneth cells, a fully committed cell population to participate in epithelial replenishment following stem cell loss.

ORGANISM(S): Mus musculus

PROVIDER: GSE113536 | GEO | 2018/06/08

REPOSITORIES: GEO