De novo lipogenesis represents a therapeutic target in Kras mutant NSCLC

ABSTRACT: We examine the potential of Kras as a metabolic target in lung cancer using the KrasLSL-G12D lung cancer model. We demonstrate that mutant Kras drives a lipogenic gene expression program, and that fatty acid synthesis is important in Kras-induced tumorigenesis. Compare gene expression changes between mutant Kras (G12D) driven lung tumors and normal lung samples to identify pathways selectively altered in lung tumors.

ORGANISM(S): Mus musculus

PROVIDER: GSE113717 | GEO | 2018/04/27

REPOSITORIES: GEO