Establishment and characterization of prostate cancer organoids [RNA-seq]

ABSTRACT: Prostate cancer translational research has been hampered by the lack of comprehensive and tractable models that represent the genomic landscape of clinical disease. Metastatic castrate-resistant prostate cancer (mCRPC) patient derived xenografts (PDXs) recapitulate the genetic and phenotypic diversity of the disease. We sought to establish a representative, preclinical platform of PDX-derived organoids that is experimentally facile for high throughput and mechanistic analysis.

ORGANISM(S): Homo sapiens

PROVIDER: GSE113741 | GEO | 2018/05/10

REPOSITORIES: GEO