Genomics

Dataset Information

44

Transcriptome of human white and brown adipose tissue biopsies


ABSTRACT: We analyzed coding transcript abundance in paired biopsies of white and brown adipose tissue obtained from the supraclavicular region of 15 healthy subjects. In a prior experiment measuring 18F-deoxyglucose uptake by PET-CT, 9 subjects displayed active brown fat and 6 did not. Overall design: Paired white and brown fat biopsies from 15 human probands, 9 brown fat positive and 6 brown fat negative judged by 18FDG-PET-CT.

INSTRUMENT(S): Illumina HiSeq 2500 (Homo sapiens)

SUBMITTER: Tobias Fromme  

PROVIDER: GSE113764 | GEO | 2018-07-06

REPOSITORIES: GEO

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Publications


Human studies suggest that a meal elevates glucose uptake in brown adipose tissue (BAT). However, in postprandial state the thermogenic activity and the metabolism of non-esterified fatty acids (NEFAs) in BAT remain unclear. Using indirect calorimetry combined with positron emission tomography and computed tomography (PET/CT), we showed that whole-body and BAT thermogenesis (oxygen consumption) increases after the ingestion of a mixed carbohydrate-rich meal, to the same extent as in cold stress.  ...[more]

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