G1P3 (IFI6), a Mitochondrial Localized Antiapoptotic Protein, Promotes Metastatic Potential of Breast Cancer Cells through mtROS

ABSTRACT: G1P3 (IFI6) was associated with poor distance metastasis free survival (DMFS) in breast cancer cases. Therefore, we tested the hypothesis that G1P3-induced mitochondrial redox deregulation confers metastatic potentials in breast cancer cells. Our results demonstrate that coordinated action of multiple pathways elicited by G1P3-induced mtROS augment actin-containing migratory structures to promote breast cancer cell migration and invasion Comparative network analysis identified upregulation of antioxidant, acin remodeling, and EMT networks in G1P3 overexpressing MCF-7 cells.

ORGANISM(S): Homo sapiens

PROVIDER: GSE113792 | GEO | 2018/05/24

REPOSITORIES: GEO