Dataset Information


Trans-differentiation of human adult peripheral blood T cells into neurons

ABSTRACT: Examining the transcriptomic changes during transdifferentiation of peripheral blood mononuclear cells to induced neuronal cells. Overall design: There are three different populations: PBMC (2 biological replicates, starting population), PSA-NCAM+GFP+ (2 biological replicates, induced neuronal cells) and PSA-NCAM+GFP- (2 biological replicates, induced neuronal cells).

INSTRUMENT(S): Illumina NextSeq 500 (Homo sapiens)

SUBMITTER: Cheen Euong Ang  

PROVIDER: GSE113804 | GEO | 2018-04-28


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Transdifferentiation of human adult peripheral blood T cells into neurons.

Tanabe Koji K   Ang Cheen Euong CE   Chanda Soham S   Olmos Victor Hipolito VH   Haag Daniel D   Levinson Douglas F DF   Südhof Thomas C TC   Wernig Marius M  

Proceedings of the National Academy of Sciences of the United States of America 20180604 25

Human cell models for disease based on induced pluripotent stem (iPS) cells have proven to be powerful new assets for investigating disease mechanisms. New insights have been obtained studying single mutations using isogenic controls generated by gene targeting. Modeling complex, multigenetic traits using patient-derived iPS cells is much more challenging due to line-to-line variability and technical limitations of scaling to dozens or more patients. Induced neuronal (iN) cells reprogrammed dire  ...[more]

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